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It is very important that you understand the rules of the Opioid Analgesic REMS program to prevent addiction, abuse, and misuse of acetaminophen and codeine combination. This medicine should come with a Medication Guide. Read and follow the instructions carefully.

Read it again each time you refill your prescription in case there is new information. Ask your doctor if you have any questions.

If you think that this medicine is not working as well after you have been taking it for a few weeks, do not increase the dose. Instead, check with your doctor. If you are using the disintegrating tablet, make sure your hands are dry before you handle it. Do not open the blister pack that contains the tablet until you are ready to take it. Remove the tablet from the blister pack by peeling back the foil, then taking the tablet out. Do not push the tablet through the foil.

Do not break, crush, or chew it. Place the tablet in your mouth. It should melt quickly. After the tablet has melted, swallow or take a sip of water.

Swallow the extended-release capsule, extended-release tablet, and tablet whole with liquids. Do not break, crush, chew, snort, or inject it. Dosing The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label.

The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For chronic pain:. For oral dosage form (extended-release capsules):. Adults—At first, 100 milligrams (mg) once a day.

Your doctor may increase your dose as needed. However, the dose is usually not more than 300 mg per day. Children 12 years of age and older—Use and dose must be determined by your doctor. Children younger than 12 years of age—Should not be used in these patients. For oral dosage form (extended-release tablets):. Adults—At first, 100 milligrams (mg) once a day. Your doctor may increase your dose as needed.

However, the dose is usually not more than 300 mg per day. Children—Use and dose must be determined by your doctor. For moderate to severe pain:. For oral dosage form (disintegrating tablets):. Adults and children 16 years of age and older—At first, 50 to 100 milligrams (mg) every 4 to 6 hours as needed.

Your doctor may increase your dose as needed. However, the dose is usually not more than 400 mg per day. Children younger than 16 years of age—Use and dose must be determined by your doctor.

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For oral dosage form (tablets):. Adults—At first, 25 milligrams (mg) per day, taken every morning. Your doctor may increase your dose as needed and tolerated. However, the dose is usually not more than 400 mg per day.

Children 12 years of age and older—Use and dose must be determined by your doctor. Children younger than 12 years of age—Should not be used in these patients. Missed Dose If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use.